Protein encapsulation in biodegradable amphiphilic microspheres
Identifieur interne : 001D06 ( Main/Exploration ); précédent : 001D05; suivant : 001D07Protein encapsulation in biodegradable amphiphilic microspheres
Auteurs : Philippe Bouillot [Royaume-Uni, France] ; Nathalie Ubrich [France] ; Françoise Sommer [France] ; Tran Minh Duc [France] ; Jean-Philippe Loeffler [France] ; Édith Dellacherie [France]Source :
- International Journal of Pharmaceutics [ 0378-5173 ] ; 1999.
Descripteurs français
- KwdFr :
- Acide lactique (), Adsorption, Eau (), Fluorescéine-5-isothiocyanate (), Fluorescéine-5-isothiocyanate (analogues et dérivés), Matériaux biocompatibles (), Microanalyse par sonde électronique, Microscopie confocale, Microsphères, Polymères (), Polyéthylène glycols (), Préparations à action retardée, Sérumalbumine bovine (), Taille de particule.
- MESH :
- analogues et dérivés : Fluorescéine-5-isothiocyanate.
- Pascal (Inist)
- Acide lactique, Adsorption, Bovin, Copolymère biséquencé, Copolymère triséquencé, Eau, Emulsion eau huile eau, Encapsulation, Ester polymère, Ethylène oxyde copolymère, Fluorescéine-5-isothiocyanate, Forme pharmaceutique, In vitro, Lactique acide polymère, Libération, Matériaux biocompatibles, Microanalyse par sonde électronique, Microscopie confocale, Microsphère, Microsphères, Polymère amphiphile, Polymère vecteur, Polymères, Polyéthylène glycols, Principe actif, Préparations à action retardée, Sérumalbumine, Sérumalbumine bovine, Taille de particule, Technologie pharmaceutique, Teneur eau, Vecteur médicament.
- Wicri :
English descriptors
- KwdEn :
- Active ingredient, Adsorption, Amphiphilic polymer, Amphiphilic properties, Biocompatible Materials (chemistry), Biodegradable, Bouillot, Bovine, Cholate, Cleaning procedure, Confocal, Confocal microscope, Control release polymer, Copolymer, Coulter multisizer, Degradation, Delayed-Action Preparations, Delivery systems, Diblock, Diblock copolymer, Diblock copolymers, Dosage form, Double emulsion method, Drug carrier, Drug delivery systems, Electron Probe Microanalysis, Emulsion, Encapsulation, Entrapped, Equal proportions, Ester polymer, Ethylene oxide copolymer, Fluorescein-5-isothiocyanate (analogs & derivatives), Fluorescein-5-isothiocyanate (chemistry), Good agreement, In vitro, International journal, Lactic Acid (chemistry), Lactic acid polymer, MPOE–PLA, Matrix, Microparticles, Microscopy, Confocal, Microsphere, Microsphere surface, Microspheres, Molecular weight, Mpoe, Mpoe chain length, Mpoe chains, Mpoe coating, Mpoe2, Mpoe5, Particle Size, Pharmaceutical technology, Pharmaceutics, Plga, Plga microspheres, Polyethylene Glycols (chemistry), Polymer, Polymers (chemistry), Protein release, Release, Release profiles, Rhodamine solution, Roughness parameters, Serum Albumin, Bovine (chemistry), Serum albumin, Sodium cholate, Supernatant, Surfactant, Triblock copolymer, Uorescent signal, Water (chemistry), Water content, Water oil water emulsion, Water uptake.
- MESH :
- chemical , analogs & derivatives : Fluorescein-5-isothiocyanate.
- chemical , chemistry : Biocompatible Materials, Fluorescein-5-isothiocyanate, Lactic Acid, Polyethylene Glycols, Polymers, Serum Albumin, Bovine, Water.
- Adsorption, Delayed-Action Preparations, Electron Probe Microanalysis, Microscopy, Confocal, Microspheres, Particle Size.
- Teeft :
- Adsorption, Amphiphilic properties, Biodegradable, Bouillot, Cholate, Cleaning procedure, Confocal, Confocal microscope, Copolymer, Coulter multisizer, Degradation, Delivery systems, Diblock, Diblock copolymer, Diblock copolymers, Double emulsion method, Drug delivery systems, Emulsion, Encapsulation, Entrapped, Equal proportions, Good agreement, International journal, Matrix, Microparticles, Microsphere, Microsphere surface, Microspheres, Molecular weight, Mpoe, Mpoe chain length, Mpoe chains, Mpoe coating, Mpoe2, Mpoe5, Pharmaceutics, Plga, Plga microspheres, Polymer, Protein release, Rhodamine solution, Roughness parameters, Sodium cholate, Supernatant, Surfactant, Uorescent signal, Water uptake.
Abstract
Abstract: MPOE–PLA microspheres containing bovine serum albumin (BSA) were prepared by the double emulsion method with high encapsulation efficiency (≈93%). Confocal scanning microscopic analysis using MPOE–PLA labelled with 1-pyrenemethanol showed the MPOE coating of the microsphere surface. This coating improves the performance of the release system compared with PLA microspheres; the hydrophilic chains reduce the BSA adsorption onto the microspheres and increase the amount of BSA released in the supernatant. Microsphere analysis using atomic force microscopy showed that the presence of the MPOE chains also leads to surface roughness. Studies of the diffusion of 1% rhodamine aqueous solution into the microspheres by means of confocal microscopy showed a fast diffusion of water through the matrices containing high molecular weight MPOE chains (>10 000 g mol−1) and could explain the fast release of BSA from these microspheres.
Url:
DOI: 10.1016/S0378-5173(99)00023-X
Affiliations:
- France, Royaume-Uni
- Alsace (région administrative), Grand Est, Lorraine (région), Provence-Alpes-Côte d'Azur
- Marseilles, Nancy, Strasbourg
- Centre national de la recherche scientifique, Laboratoire réactions et génie des procédés, Université Strasbourg 1, Université de Lorraine
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Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Active ingredient</term>
<term>Adsorption</term>
<term>Amphiphilic polymer</term>
<term>Amphiphilic properties</term>
<term>Biocompatible Materials (chemistry)</term>
<term>Biodegradable</term>
<term>Bouillot</term>
<term>Bovine</term>
<term>Cholate</term>
<term>Cleaning procedure</term>
<term>Confocal</term>
<term>Confocal microscope</term>
<term>Control release polymer</term>
<term>Copolymer</term>
<term>Coulter multisizer</term>
<term>Degradation</term>
<term>Delayed-Action Preparations</term>
<term>Delivery systems</term>
<term>Diblock</term>
<term>Diblock copolymer</term>
<term>Diblock copolymers</term>
<term>Dosage form</term>
<term>Double emulsion method</term>
<term>Drug carrier</term>
<term>Drug delivery systems</term>
<term>Electron Probe Microanalysis</term>
<term>Emulsion</term>
<term>Encapsulation</term>
<term>Entrapped</term>
<term>Equal proportions</term>
<term>Ester polymer</term>
<term>Ethylene oxide copolymer</term>
<term>Fluorescein-5-isothiocyanate (analogs & derivatives)</term>
<term>Fluorescein-5-isothiocyanate (chemistry)</term>
<term>Good agreement</term>
<term>In vitro</term>
<term>International journal</term>
<term>Lactic Acid (chemistry)</term>
<term>Lactic acid polymer</term>
<term>MPOE–PLA</term>
<term>Matrix</term>
<term>Microparticles</term>
<term>Microscopy, Confocal</term>
<term>Microsphere</term>
<term>Microsphere surface</term>
<term>Microspheres</term>
<term>Molecular weight</term>
<term>Mpoe</term>
<term>Mpoe chain length</term>
<term>Mpoe chains</term>
<term>Mpoe coating</term>
<term>Mpoe2</term>
<term>Mpoe5</term>
<term>Particle Size</term>
<term>Pharmaceutical technology</term>
<term>Pharmaceutics</term>
<term>Plga</term>
<term>Plga microspheres</term>
<term>Polyethylene Glycols (chemistry)</term>
<term>Polymer</term>
<term>Polymers (chemistry)</term>
<term>Protein release</term>
<term>Release</term>
<term>Release profiles</term>
<term>Rhodamine solution</term>
<term>Roughness parameters</term>
<term>Serum Albumin, Bovine (chemistry)</term>
<term>Serum albumin</term>
<term>Sodium cholate</term>
<term>Supernatant</term>
<term>Surfactant</term>
<term>Triblock copolymer</term>
<term>Uorescent signal</term>
<term>Water (chemistry)</term>
<term>Water content</term>
<term>Water oil water emulsion</term>
<term>Water uptake</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acide lactique ()</term>
<term>Adsorption</term>
<term>Eau ()</term>
<term>Fluorescéine-5-isothiocyanate ()</term>
<term>Fluorescéine-5-isothiocyanate (analogues et dérivés)</term>
<term>Matériaux biocompatibles ()</term>
<term>Microanalyse par sonde électronique</term>
<term>Microscopie confocale</term>
<term>Microsphères</term>
<term>Polymères ()</term>
<term>Polyéthylène glycols ()</term>
<term>Préparations à action retardée</term>
<term>Sérumalbumine bovine ()</term>
<term>Taille de particule</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Fluorescein-5-isothiocyanate</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Biocompatible Materials</term>
<term>Fluorescein-5-isothiocyanate</term>
<term>Lactic Acid</term>
<term>Polyethylene Glycols</term>
<term>Polymers</term>
<term>Serum Albumin, Bovine</term>
<term>Water</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Fluorescéine-5-isothiocyanate</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adsorption</term>
<term>Delayed-Action Preparations</term>
<term>Electron Probe Microanalysis</term>
<term>Microscopy, Confocal</term>
<term>Microspheres</term>
<term>Particle Size</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Acide lactique</term>
<term>Adsorption</term>
<term>Bovin</term>
<term>Copolymère biséquencé</term>
<term>Copolymère triséquencé</term>
<term>Eau</term>
<term>Emulsion eau huile eau</term>
<term>Encapsulation</term>
<term>Ester polymère</term>
<term>Ethylène oxyde copolymère</term>
<term>Fluorescéine-5-isothiocyanate</term>
<term>Forme pharmaceutique</term>
<term>In vitro</term>
<term>Lactique acide polymère</term>
<term>Libération</term>
<term>Matériaux biocompatibles</term>
<term>Microanalyse par sonde électronique</term>
<term>Microscopie confocale</term>
<term>Microsphère</term>
<term>Microsphères</term>
<term>Polymère amphiphile</term>
<term>Polymère vecteur</term>
<term>Polymères</term>
<term>Polyéthylène glycols</term>
<term>Principe actif</term>
<term>Préparations à action retardée</term>
<term>Sérumalbumine</term>
<term>Sérumalbumine bovine</term>
<term>Taille de particule</term>
<term>Technologie pharmaceutique</term>
<term>Teneur eau</term>
<term>Vecteur médicament</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Adsorption</term>
<term>Amphiphilic properties</term>
<term>Biodegradable</term>
<term>Bouillot</term>
<term>Cholate</term>
<term>Cleaning procedure</term>
<term>Confocal</term>
<term>Confocal microscope</term>
<term>Copolymer</term>
<term>Coulter multisizer</term>
<term>Degradation</term>
<term>Delivery systems</term>
<term>Diblock</term>
<term>Diblock copolymer</term>
<term>Diblock copolymers</term>
<term>Double emulsion method</term>
<term>Drug delivery systems</term>
<term>Emulsion</term>
<term>Encapsulation</term>
<term>Entrapped</term>
<term>Equal proportions</term>
<term>Good agreement</term>
<term>International journal</term>
<term>Matrix</term>
<term>Microparticles</term>
<term>Microsphere</term>
<term>Microsphere surface</term>
<term>Microspheres</term>
<term>Molecular weight</term>
<term>Mpoe</term>
<term>Mpoe chain length</term>
<term>Mpoe chains</term>
<term>Mpoe coating</term>
<term>Mpoe2</term>
<term>Mpoe5</term>
<term>Pharmaceutics</term>
<term>Plga</term>
<term>Plga microspheres</term>
<term>Polymer</term>
<term>Protein release</term>
<term>Rhodamine solution</term>
<term>Roughness parameters</term>
<term>Sodium cholate</term>
<term>Supernatant</term>
<term>Surfactant</term>
<term>Uorescent signal</term>
<term>Water uptake</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Bovin</term>
<term>Polymère</term>
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<front><div type="abstract" xml:lang="en">Abstract: MPOE–PLA microspheres containing bovine serum albumin (BSA) were prepared by the double emulsion method with high encapsulation efficiency (≈93%). Confocal scanning microscopic analysis using MPOE–PLA labelled with 1-pyrenemethanol showed the MPOE coating of the microsphere surface. This coating improves the performance of the release system compared with PLA microspheres; the hydrophilic chains reduce the BSA adsorption onto the microspheres and increase the amount of BSA released in the supernatant. Microsphere analysis using atomic force microscopy showed that the presence of the MPOE chains also leads to surface roughness. Studies of the diffusion of 1% rhodamine aqueous solution into the microspheres by means of confocal microscopy showed a fast diffusion of water through the matrices containing high molecular weight MPOE chains (>10 000 g mol−1) and could explain the fast release of BSA from these microspheres.</div>
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<name sortKey="Loeffler, Jean Philippe" sort="Loeffler, Jean Philippe" uniqKey="Loeffler J" first="Jean-Philippe" last="Loeffler">Jean-Philippe Loeffler</name>
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<name sortKey="Ubrich, Nathalie" sort="Ubrich, Nathalie" uniqKey="Ubrich N" first="Nathalie" last="Ubrich">Nathalie Ubrich</name>
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